It is generally used alongside active ingredients in pharmaceutical drugs and dietary supplements. It is commonly used in tablets prepared by either direct-compression or wet-granulation processes. It is used as a disintegrant, a suspending agent and as a gelling agent. Sodium Starch Glycolate. Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. 2004 Jul 14;6(3):e17. Thereafter, the said active ingredients are broken down in areas where absorption occurs with their maximum effectiveness preserved. Being the sodium salt of carboxymethyl ether, Sodium Starch Glycolate is a white to off-white, odourless, tasteless, free-flowing powder. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 9063-38-1. Overview of pharmaceutical excipients used in tablets and capsules. Please enable it to take advantage of the complete set of features! AAPS PharmSciTech. It is manufactured by chemical modification of starch . (Na)x CAS Number: 9063-38-1 NACRES: NA.24 Pricing and availability is not currently available. Nonetheless, it should be used only within the range of its Acceptable Daily Intake to prevent any untoward reactions. It is widely recognised in the pharmaceutical industry for its adaptability and compatibility with many active pharmaceutical ingredients, and processing technologies. operation in the dark. Main Export Market (s): Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa. It may contain NMT 7.0% of Sodium N = normality of the perchloric acid Chloride. The pH and assay requirements for Type A and W = weight of the dried alcohol-insoluble . As to Assay Sodium, the ranges for Types A, B and C are 2.8% to 4.2%, 2.0% to 3.4%, and 2.8% to 5.0%, respectively. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This was the original procedure published in PF 30(4). Sodium glycolate | C2H3NaO3 - PubChem Apologies, we are having some trouble retrieving data from our servers. Get free samples, pricing and stock list. It is used as a disintegrant, a suspending agent and as a gelling agent. EXPLOTAB, sodium starch glycolate, is a superdisintegrant made from potato starch by carboxymethylation and crosslinking. WHAT IS SODIUM STARCH GLYCOLATE? Return this item for free. The compound may be purchased in bulk or lesser quantities from legitimate ingredient suppliers like Nutriavenue. Sodium starch glycolate Synonym: More Synonyms Chemical & Physical Properties. (C2H4NaO3)x. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Diosgenin: A Plant Steroid for Improved Hormonal Balance, 2 Main Manufacturing Processes Of NMN Crystalline Powder, Dec. 7th Ingredients Price: Recommended Alpha Lipoic Acid, Nutritional Vitamin Ingredients Market 2022: Status, Development & Forecast, Key Country Dietary Supplement Market Overview 2022. Sample Available: Yes. 2004. http://www.pformulate.com/nastgly.htm Accessed October 17, 2011. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Data sources include IBM Watson Micromedex (updated 2 Dec 2022), Cerner Multum (updated 7 Dec 2022), ASHP (updated 11 Nov 2022) and others. Read-more Registered trademark (s) of Roquette Frres Documents and Samples Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness. This results in swelling which eventually causes the breakdown of the active ingredients first into granules then into fine particles. It also works as a thickening agent. Sodium Starch Glycolate may also be used as a gelling agent. [1] [2]. Excipient (pharmacologically inactive substance). The options from the pharmacist were to make calls to the manufacturers, or she offered . The Sodium Chloride content of Types A and B is at a maximum of 7% while the Sodium Chloride content of Type C is at a maximum of 1%. Color reaction Reagent required 0.005M Iodine Procedure: Dissolve 2 g sample and disperse in 100 ml of water. A revision to the harmonized standard for Sodium Starch Glycolate has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG Stage 6 sign-off Rev. It is used as a disintegrant, a suspending agent and as a gelling agent. Add 5mol/L acetic acid solution and 5ml water to the Beaker, stir for about 15 minutes until sodium glycolate dissolves; Add 50ml acetone and lg sodium chloride, the mixture was stirred to completely precipitate the carboxymethyl starch, filtered, and the filtrate was placed in a 100ml measuring flask . While the compound was initially thought to be an inactive ingredient as it does not produce direct effects on individual users, it was later found that it plays an important role in pharmacodynamics and pharmacokinetics. The Properties, Specifications, Monograph and Uses of Sodium Starch Glycolate: CAS Number 9063-38-1, EINECS EC Number 618-597-7, HS Code 29389090. It is produced by cross-linking and carboxy methylation of potato starch. Compendial assays provide an accurate representation of the chemical quality of an excipient, but they are not useful in describing the physical properties associated with the excipients. Starch glycolates are also of rice, wheat or corn origin. This action of the compound essentially results in higher bioavailability of active ingredients and improved dissolution rates. Their unique combination of performance and cost-effectiveness has established them as globally recognized and widely used products in the pharmaceutical industry. It offers excellent formulation and commercial benefits to the pharmaceutical industry and demonstrates strong swelling properties upon contact with water and other media. Sodium starch glycolate is the sodium salt of carboxymethyl ether. As a dissolution excipient, Sodium Starch Glycolate works as a disintegrant. Check ingredients faster with the free Fig app! Customers may also avail of other options for packaging depending on their preference. The following are among the well-known uses of Sodium Starch Glycolate: As a dissolution excipient, Sodium Starch Glycolate helps maintain effectiveness of active ingredients in tablets and capsules. It is otherwise known for its other generic names which include SSG, Sodium salt of Carboxymethyl Ether, Carboxymethyl Starch Sodium salt, Sodium Starch Glycolate Type A potato, and Sodium Starch Glycolate Type B. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. The color of SSG varies from white to off-white tone. Our GLYCOLYS product provides this benefit for swallowable tablets, orally dispersible tablets and hard capsules. It is described as having a white to off-whitish free-flowing powder appearance. The Acceptable Daily Intake (ADI) for Sodium Starch Glycolate is at 13mg/kg body weight per day among adults and 80 mg/kg body weight per day among children. Advanstar. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium starch glycolate (type A) EUROPEAN PHARMACOPOEIA 6.0 Sulphates and selenates(2.4.13): maximum 300 ppm (determined as sulphates). Unable to load your collection due to an error, Unable to load your delegates due to an error. Medically reviewed by Drugs.com. I just returned from the doctor and pharmacy and I am so frustrated. 9057-06-1 (free acid) Appearance. Its property of insolubility is remarkable, with complete insolubility in most organic solvents, and even in water. Being strict to quality, we follow ethical manufacturing practices and bring products that comply with defined industry standards. Glycolic acid is widespread in nature. Contact us to discuss how we can help you address your formulation needs! Sodium Starch Glycolate is a typical super-disintegrant used to accelerate rapid disintegration and dissolution of IR solid dosage forms. Specification. Sodium Starch Glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. The .gov means its official. 2004. http://www.pformulate.com/nastgly.htm Accessed October 17, 2011. Studies show that Sodium Starch Glycolate is also very beneficial in improving medication bioavailability. Changed description of procedure to align with the PDG Stage 6 sign-off document, including add 2mL of 15% potassium carbonate, and heat to boiling. To 2 ml of solution S add 2 ml of a 200 g/l solution of Sodium starch glycolate (SSG) is a viscous and thixotropic thickening agent that can be used in gravy, sauces, salad dressing and other products. Common Chemistry CAS Common Chemistry is an open community resource of the American Chemical Society for accessing chemical information. Under the guidelines of this diet, croscarmellose sodium should be specifically avoided because of its ability to promote overgrowth of flora, both good and bad. Country: India Phone: +91-79-26431096 Telefax: +91-79-26569884. It may contain not more than 7.0 percent of Sodium Chloride. Advanstar. It is a white to off-white, tasteless, odorless, relatively free-flowing powder. For more information on our products or to get a free quote, you may visit our website and inquire from our friendly and customer-oriented technical support staff. My doctor wrote 2 prescriptions. Careers. Research also shows that Sodium Starch Glycolate may work as a suspending excipient agent. The pH and assay requirements for Type A and Type B are set forth in the accompanying table. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Source of Sodium Starch Glycolate SSG is available in the starchy substance of potato & corn. It is used as a disintegrant, a suspending agent and as a gelling agent. Sodium Starch Glycolate, are potato based cellulose fibers have been cross linked - that is, have been either ionically or covalently bonded, so that it forms a chain of cellulose, rather than individual, short fibers. Physical characterization of sodium starch glycolate, NF revealed differences in particle size, surface area, porosity, surface morphology, and viscosity between two of the three sources examined. Highly effective when used intra- and extra-granularly in wet and dry granulated formulations. These include Sodium Starch Glycolate powder, Sodium Starch Glycolate granule, and Sodium Starch USP Standard. AAPS J. Sodium Starch Glycolate is the sodium salt of carboxymethyl ether of starch classified as a disintegrant and an excipient. Sodium glycocholate | C26H42NNaO6 - PubChem Apologies, we are having some trouble retrieving data from our servers. Drug Topics (online). These active ingredients are protected from breaking down prematurely while passing through the digestive tract. CARBOXYMETHYL STARCH SODIUM SALT explotab SODIUM STARCH GLYCOLATE CARBOXYMETHYL STARCH SODIUM Sodium [(3R,4S,5R)-4,5-dihydroxy-6-methoxy-3-methyltetrahydro-2H-pyran-2-yl . Epub 2020 Jan 24. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages. All Spectrum Chemical NF grade products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities. 9063-38-1 - Sodium starch glycolate - Searchable synonyms, formulas, resource links, and other chemical information. 100 INR Get latest price. Federal government websites often end in .gov or .mil. Effect of a disintegration mechanism on wetting, water absorption, and disintegration time of orodispersible tablets. Sodium Starch Glycolate. Medically reviewed by Drugs.com. doi: 10.1208/aapsj060317. Sodium Starch Glycolate, or SSG, is a cross-linked variant of Carboxymethyl starch. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. These are SSG Type A, SSG Type B, and SSG Type C. Essentially, Types A and B of Sodium Starch Glycolate are cross-linked salts of sodium that are partly O-carboxymethylated potato starch. We comply with the HONcode standard for trustworthy health information. A glycolate (sometimes spelled "glycollate") is a salt or ester of glycolic acid. Sodium Starch Glycolate is the sodium salt of a carboxymethyl ether of starch or of a cross-linked carboxymethyl ether of starch. At what percentage starch can be used as Disintegrant? Please see the NLM Technical Bulletin article for more information. There are also other minor verbiage changes to align with PDG Stage 6 sign-off document. Zarmpi P, Flanagan T, Meehan E, Mann J, Fotaki N. Int J Pharm. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. This diet limited complex carbohydrates and refined sugar in the attempt to stop symptoms of Crohn's disease, irritable bowel syndrome and celiac disease. Fig's dietitians reviewed this note on sodium starch glycolate. Sodium starch glycolate is utilized as a pharmaceutical review dissolution excipient for tablets and capsules. Sodium starch glycolate (SSG) is a superdisintegrant suitable for a variety of tablet and capsule formulations. Download the Sodium Starch Glycolate PDG Stage 6 sign-off Cover Pages. Sodium Starch Glycolate is gluten free. Sodium Starch Glycolate Type A (400 mg) Catalog No: 1614669 CAS RN 9063-38-1 Molecular Formula: C2H4O3.xNa.xUnspecified Product Type: Reference Standard remove Add to Cart star Add to Favorites Shipping Information Current Lot Information Current Lot: H1L048 CAS RN 9063-38-1 Harmonized System (HS) Code *: 350510 UN No: N/A NDC No: N/A It is practically insoluble in water and also in most organic solvents. Starch glycolates are of rice, potato, wheat or corn origin. Sodium Starch Glycolate has been previously approved by the Food and Drug Administration for use as a disintegrant in prescription and over-the-counter medications. 7. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Acta Pol Pharm. GLYCOLYS Sodium starch glycolate provides pharmaceutical and nutraceutical manufacturers with a range of superdisintegrants for different formulation needs. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Effects of modification and incorporation techniques on disintegrant properties of wheat (Triticum aestivum) starch in metronidazole tablet formulations. It improves supplement ingredient combination The combination of ingredients in a supplement product may also be improved with compounds such as Sodium Starch Glycolate. sharing sensitive information, make sure youre on a federal GLYCOLYS Sodium starch glycolate is a range of superdisintegrants for different formulation needs. CAS. 67 Requirements 68 Definition. This site needs JavaScript to work properly. Sodium starch glycolate is the sodium salt of carbomethyl ether. Find here Sodium Starch Glycolate, CAS No- 9063-38-1 exporters & OEM exporters India. Contents 1 History 2 Preparation Excipients. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. Sodium Starch Glycolate By Maruti Chemicals. Roquette has been producing sodium starch glycolate for more than 20 years. Crosslinked polymers: crosslinked polyvinylpyrrolidone (crospovidone), crosslinked sodium carboxymethyl cellulose (croscarmellose sodium). Pharm Dev Technol. Drug Topics (online). (Na)x CAS Number: 9063-38-1 NACRES: NA.24 Pricing and availability is not currently available. It's a white to off-white powder that's odorless, tasteless, and free . Road, Regal Square, 4 Years Member Since : 4 Years Accepts only Domestic Inquiries 4 Buyer Feedback View Number Send Inquiry Data sources include IBM Watson Micromedex (updated 2 Dec 2022), Cerner Multum (updated 7 Dec 2022), ASHP (updated 11 Nov 2022) and others. It is made by modifying starch chemically, such as carboxymethylation to increase hydrophilicity and cross-linking to decrease solubility. Sodium starch glycoate is a white to off-white, tasteless,. Generally, the compound works by absorbing water several times its weight when ingested orally. 2001 Aug;6(3):419-30. doi: 10.1081/pdt-100002250. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Available for Android and iOS devices. Sodium starch glycolate type A potato is the sodium salt of carboxymethyl ether of starch from potato origin. Sodium starch glycolate is the sodium salt of carboxymethyl ether. sodium glycolate. Each drum contains a net weight of about 25 kilograms. It can also be manufactured from other starch foods such as corn, wheat, and rice. Type C, however, is manufactured through physical dehydration by cross-linking of sodium salt of partly carboxymethylated starch. Sodium starch glycolate is very hygroscopic. The action was assigned pesticide petition (PP . Sodium Starch Glycolate can be used in the synthesis of capsules for delivery of drugs or medicaments. Price: $34.57. Sample Policy: Within a certain price range free samples are available. The botanic source and degrees of cross-linking and substitution have been optimized to give rapid water uptake . 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Roquette's application experts are available to help you formulate innovative solutions. Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution. Lowering the pH of the medium reduced the rate and extent of liquid uptake and the settling volume in all instances. Sodium Starch Glycolate is a pharmaceutical excipient and superdisintegrant composed of the sodium salt of cross-linked carboxymethyl starch. The use of SSG (Sodium Starch Glycolate) can produce a faster disintegration time than amprotab (Rohmani and Rosyanti, 2019) . Disclaimer, National Library of Medicine An automated liquid uptake test (in neutral and acidic medium) demonstrated similar initial rates of uptake, however, the extent of liquid uptake differed for the disintegrant powders examined. Sodium Starch Glycolate is a very fine free flowing powder that is white or off white in color and has almost no odor. It is a white to off-white, tasteless, odorless, relatively free-flowing powder. *Should you have any questions about the Sodium Starch Glycolate monograph, please contact Dr. Tong (Jenny) Liu (240-221-2072 or jyl@usp.org). J Pharm Sci. Sodium starch glycolate type A potato is the sodium salt of carboxymethyl ether of starch from potato origin. It also works as a disintegrant and a gelling agent. The site is secure. Important Announcement. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. An official website of the United States government. The extent of liquid uptake and settling volume was observed to be higher for the smaller sieve fractions in either medium, Although differences were also observed in the axial and radial disintegration force measurements of the pure disintegrant compacts, disintegration and dissolution of a model drug (hydrochlorothiazide) from either the soluble or insoluble core did not reveal any significant differences between the multiple sources. II. Also, the compound is safely used for the said purpose in dietary supplement products. Bethesda, MD 20894, Web Policies The Sodium Starch Glycolate monograph will be incorporated into and become official with the Second Supplement to USP 37-NF 32. Sodium starch glycolate is the sodium salt of carboxymethyl ether. Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants. Sodium Starch Glycolate should be safe for patients with celiac and other gluten-related disorders. Effect of molecular structure variation on the disintegrant action of sodium starch glycolate. Glycolic acid (or hydroxyacetic acid; chemical formula HOCH 2 CO 2 H) is a colorless, odorless and hygroscopic crystalline solid, highly soluble in water. Thus, it helps stabilize active ingredients in medications and dietary supplement products. IDENTIFICATION OF PHARMACEUTICAL EXCIPIENT BEHAVIOR OF CHICKPEA (CICER ARIETINUM) STARCH IN GLICLAZIDE IMMEDIATE RELEASE TABLETS. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. Get Contact details & address of companies manufacturing and supplying Sodium Starch Glycolate, CAS No- 9063-38-1 across India. Primojel sodium starch glycolate is a superdisintegrant suitable for various tablet and capsule formulations. MOQ: 20000 Kilograms. Settling volume was also observed to be different for the disintegrant from two sources. National regulations Germany AwSV/VwVwS Annex reference : Water hazard class (WGK) 1, slightly hazardous to water (Classification according to VwVwS, Annex 3; WGK No 2988) It is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility. Sodium Starch Glycolate Market - Insights: The Sodium Starch Glycolate industry is estimated to grow at a significant CAGR in the upcoming period as the scope and its applications are rising . Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Sodium Starch Glycolate is considered practically insolvent in water and many organic solvents. In a letter to the Agency dated June 28, 1994, Generichem Corp, now located at 755 Union Boulevard in Totowa, New Jersey 07511-0457 requested that 40 CFR 180.1001 (c) and (e), be amended by establishing an exemption from the requirement of a tolerance for residues of sodium starch glycolate. Would you like email updates of new search results? Properties Grade pharmaceutical primary standard manufacturer/tradename USP application (s) pharmaceutical (small molecule) neat CAS: 9063-38-1 Synonyms: Sodium Carboxymethyl Starch Sodium Starch Glycolate, pH 5.5-7.5, Type A, NF is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Molecular Formula. 2.7.2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Accessed 08/19/2011, Pformulate. Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. 66 Additional information. The compound is also tasteless and generally odorless. Is Fadogia Agrestis Illegal in the Market? Evaluation of the functional equivalence of crospovidone NF from different sources. Primojel is highly effective when used intragranular and/or extragranular in dry/wet granulation processes. Standard performance test. Overview of pharmaceutical excipients used in tablets and capsules. [1] [2]. Zolpidem Tartrate Extended-Release 6.25 mg, Zolpidem Tartrate Extended-Release 12.5 mg, [1]Dave RH. The chemical information in the CAS database is curated by expert scientists and includes information of common and frequently regulated . No precipitate is formed. and heat to boiling. Types A, B, and C of Sodium Starch Glycolate differ in terms of pH, Sodium Chloride content, and Assay Sodium. USA address: 1641 W Main St, Ste 222, Alhambra, CA 91801China address:Room 209 , Huana Business Center , NO 1733 Lianhua Road , Minhang District , Shanghai , China 201103. This means that it may be useful in protecting active ingredients from caking at the bottom of the drug or dietary supplement form and maintain their suspension in the formulation. Sodium starch glycoate is a white to off-white, bland, odorless, moderately free streaming powder. It is mostly used in the manufacturing of paper, pulp, dyeing, textiles, detergents, cosmetics . Sodium starch glycolate was chosen because of its high swelling capacity. Starch glycolates are of rice, potato, wheat or corn origin. 2016 Mar-Apr;73(2):469-78. You can return the item for any reason in new and unused condition: no shipping charges. Free returns are available for the shipping address you chose. Sodium Starch Glycolate (Maize & Potato), 25Kg 250/ Kg Get Latest Price Packaging Size: 25Kg Grade Standard: BP Purity: >99% Manufacturer: Jai Radhe Saless Grade: Pharma Grade Packaging Type: Drum read more. . B. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) ( Shah & Augsburger, 2002 ). The Sodium Starch Glycolate monograph will be incorporated into and become official with the Second Supplement to USP 37NF 32. Sodium starch glycolate is the sodium salt of a cross-linked partly O-69 carboxymethylated starch. The ADI may vary depending on the individual users age, weight, and overall physical condition. 2012 Jul;4(3):157-63. doi: 10.4103/0975-1483.100021. EXPLOTAB , sodium starch glycolate, is a superdistintegrant made from potato starch by carboxymethylation and crosslinking for tablets and other oral solid dosage forms. Sodium starch glycolate is an organic compound produced by the reaction of sodium hydroxide and starch. Accessibility It has been reported in the literature that the source of starch, particle size, amount of sodium chloride (reaction by-product), viscosity, degree of substitution and cross-linking affect the functionality of sodium starch glycolate. Our company offers high-quality products at very affordable prices. In higher concentrations, it can act as a dissolution enhancing agent. MeSH This revision to the Sodium Starch Glycolate monograph has been formally approved by the USP MonographsExcipients Expert Committee in accordance with the Rules and Procedures of the 20102015 Council of Experts. 1985 Jun;74(6):647-50. doi: 10.1002/jps.2600740613. Considering that it is an inert compound having no active ingredient properties, it is considered safe for use among individual users. It is white to off-white, odorless, tasteless, and free-flowing powder. Conclusions: The tablet consisting of stevia, crospovidone, lactose, and magnesium stearate at the weight ratio of 15/2.5/32/0.5 showed excellent results with regards to dissolution and disintegration; accordingly, this formulation could be a potential sugar substitute for diabetic, obese and/or calorie-conscious individuals. We have developed different grades of TABSOL to meet specific needs, such as withstanding high shear granulation, acidic conditions or with a . official website and that any information you provide is encrypted If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health Sodium Starch Glycolate is considered practically insolvent in water and many organic solvents. 2.7.2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Posted May 4, 2018. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Type of Posting: Notice of Adoption of Harmonized Standard, Posting Date: 28Feb2014 (updated 28Feb2017*). Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Jai Radhe Sales is supplier for Sodium starch glycolate. 2020 Mar 15;577:119080. doi: 10.1016/j.ijpharm.2020.119080. Description. Formulation design of double-layer in the outer shell of dry-coated tablet to modulate lag time and time-controlled dissolution function: studies on micronized ethylcellulose for dosage form design (VII). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Help; FAQs; Last updated on Dec 6, 2021. X. ChemIDplus is moving to PubChem in December 2022. Nitika has been producing Sodium Starch Glycolate for more than 20 years. *Should you have any questions about the Sodium Starch Glycolate monograph, please contact Dr. Tong (Jenny) Liu (240-221-2072 or jyl@usp.org ). The usual concentration of Solvostar . It is usually packed in paper drums with two layers of poly bags inside when purchased in bulk. It is used in various skin-care products. Sodium Starch Glycolate. SSG has more hydrophilic substitution than its hydrophilic group,. Starch is chemically modified by the introduction of carboxy methyl groups and phosphate groups to provide cross-linking. Take 5 ml of above dispersion and add 0.05 ml 0.005M iodine. Carboxymethyl Ether sodium salt The CAS number for Carboxymethyl Ether sodium salt or Sodium Starch Glycolate is 9063-38-1. FOIA Its unique combination of performance and cost-effectiveness has established as globally recognized and widely used product in the pharmaceutical industry. HiMedia GRM7519-500G Sodium Starch Glycolate, Extra Pure, 500 g. Brand: HiMedia. government site. SODIUM STARCH GLYCOLATE EXTRA PURE is not on the REACH Candidate List SODIUM STARCH GLYCOLATE EXTRA PURE is not on the REACH Annex XIV List 15.1.2. BBF-04564. Starch glycolates are of rice, potato, wheat or corn origin. Bookshelf The use of Sodium Starch Glycolate in drugs and dietary supplement products has been shown to increase the effectiveness of active ingredients as the compound helps improve overall bioavailability. Generally, there are no side effects associated with Sodium Starch Glycolate supplementation as it does not have a direct effect on individual users. This product is used as a pharmaceutical-grade dissolution agent and super disintegrant which is . Related CAS. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium starch glycolate, form by the starch carboxymethylation, substitution value is 0.1-1 (butt calculating), viscosity is 10-1000 centipoises (butt calculates, 2% concentration, 25 ), at normal temperatures can be water-soluble fully, good stability, perviousness is strong, can be widely used in fields such as weaving, printing and dyeing, papermaking, food, medicine, oil recovery.Its . Nutriavenue is an FDA-registered ingredient supplier which is recognized by Halal, Kosher, and GMP. PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine If you are looking for a place to buy bulk Sodium Starch Glycolate powder, Nutriavenue is the best choice. It must be distinguished from Carboxymethylcellulose sodium which is often used as a bulk-forming agent and a laxative. Skip Navigation. *The previous sign-offs and Stage 6 postings are included as below: Promoting the Quality of Medicines Plus (PQM+) Program, Download the Sodium Starch Glycolate monograph, 15-Nov-2021, Rev.3 (Correction of Sign-Off Cover Sheet), Previous Stage 6 posting in PF 30 (4), 2004, The United States Pharmacopeial Convention, Minor verbiage changes to align with the PDG Stage 6 sign-off document. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium Starch Glycolate is the sodium salt of a carboxy-methyl ether of starch or of a cross-linked carboxymethyl V = volume of perchloric acid consumed (mL) ether of starch. Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. Type A contains not less than 2.8% and not more than 4.2% sodium starch glycolate, a modified starch; Flavours. Dissolve 0.5 g in 10 ml ofdistilled water R.Add0.5mlof hydrochloric acid R1 and dilute to 15 ml with distilled water R. Iron:maximum50ppm. 8 Moreover, the disintegrant efficiency of sodium starch glycolate is unimpaired by the presence of hydrophobic. 8600 Rockville Pike Sodium Starch Glycolate is a pharmaceutical ingredient used primarily as a dissolution excipient for tablets and capsules. Available for Android and iOS devices. Allow to cool in ice water. Sodium Starch USP Standard comes in varieties such as type A, type B, PH, and those with sodium content. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Sodium starch glycolate is the sodium salt of carboxymethyl ether. The https:// ensures that you are connecting to the It must be distinguished from Carboxymethylcellulose sodium which is often used as a bulk-forming agent and a laxative. How can we help? SSG powder is odorless, tasteless, hygroscopic & free-flowing. Technical inquiry about: 45-1614669 Sodium Starch Glycolate Type A. Sulfamethoxazole and Trimethoprim 800 mg / 160 mg, Sulfamethoxazole and trimethoprim DS 800 mg / 160 mg, Dave RH. Sodium starch glycolate absorbs water rapidl More Nakoda Corporation Indore, India 208-209, Sheba Complex, 562, M.G. The IR absorption spectrum of the sample is concordant with the reference spectrum or with the spectrum obtained from sodium starch glycolate WRS. There are three major types of Sodium Starch Glycolate. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) ( Shah & Augsburger, 2002 ). $34.57 FREE Returns. Solvostar - Sodium starch glycolate (SSG) is widely used in oral pharmaceuticals as a disintegrate in tablet and capsule formulations. Silverline Chemicals - one of the best Sodium Starch Glycolate USP/BP/EP/PH.EUR Manufacturers in India, offers a wide variety of products processed at our in-house facility using premium material and advanced resources. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Excipients. It is a sodium salt of carboxyl ether of starch, and is appreciated for its stability and binding properties. The physical properties of sodium starch glycolate remain unchanged for up to 3 years if it is stored at moderate temperatures and humidity. BlowTab - Sodium Starch Glycolate. Clipboard, Search History, and several other advanced features are temporarily unavailable. Certificate of Analysis. Sodium Starch Glycolate contains about 2.8 to 5.0 percent of Sodium, depending on its type, and not more than 7 percent of Sodium Chloride. 3 cover sheet. We also offer shipping services through the air, sea, or couriers like FedEx or UPS. A dark blue color is . PMC In higher concentrations, Primojel can act as a dissolution enhancing agent. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The CAS number for Carboxymethyl Ether sodium salt or Sodium Starch Glycolate is 9063-38-1. The designation on the container of Sodium starch glycolate should state its 65 type. Starch glycolates are also of rice, wheat or corn origin. Several forms of Sodium Starch Glycolate are available in the market. Molecular Formula: C 10 H 19 NaO 8: Molecular Weight: 290.243: Exact Mass: 290.097748: . Starch glycolates are of rice, potato, wheat or corn origin. We comply with the HONcode standard for trustworthy health information. VIVASTAR & EXPLOTAB, sodium starch glycolate, are superdistintegrants made from potato starch by carboxymethylation and crosslinking for tablets and other oral solid dosage forms. Before Properties grade pharmaceutical primary standard manufacturer/tradename Sodium starch glycolate is stable although very hygroscopic, and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking. J Young Pharm. Thus, its inclusion in formulations for drugs and dietary supplement products is not negligible but rather quite significant. HHS Vulnerability Disclosure, Help Sodium Starch Glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. Flavours can be used to mask unpleasant tasting active ingredients and improve the acceptance that the patient will complete a course of medication . Sodium Starch Glycolate can be used in the synthesis of capsules for delivery of drugs or medicaments. 1, a kind of manufacture method of sodium starch glycolate, comprise by starch, sodium hydroxide and mono chloro acetic acid carry out carboxymethylation reaction, it is characterized in that. Founded in 1999, Jai Radhe Sales is a customer focused exporter of Active Pharmaceutical Ingredients, Agro Chemicals, Pellets, Phyto chemicals, Excipients & Fine Chemical s. We are seller of Tizanidine hydrochloride. Changes from the existing USPNF monograph include revisions to existing tests: In addition, the monograph has been edited to be consistent with the current USP style guide. SODIUM STARCH GLYCOLATE TYPE B POTATO [II] Common Name; UNII Resources. and transmitted securely. Type B, in contrast, has a pH level of 3.0 to 5.0. Brand names for the compound include Primojel, EXPLOTAB, and GLYCOLYS. It is believed that Sodium Starch Glycolate works as a suspending agent by filming around active ingredient particles and decreasing inter-particulate attraction. When I went to pick them up from the pharmacy, I discovered they both list sodium starch glycolate in the inactive ingredient list. 2021 Jun 16;22(5):183. doi: 10.1208/s12249-021-02056-0. Last updated on Jan 17, 2022. Excipient (pharmacologically inactive substance). For any questions about the PDG and its processes, please see the Pharmacopeial Harmonization Group or contact Richard Lew at (240-221-2060 or rll@usp.org). Rates for shipping may vary depending on the number of products you purchase and your location. TABSOL - Sodium starch glycolate is pharmaceutical and nutraceutical superdisintegrants for different formulation needs. It is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility. National Library of Medicine. Both Type A and Type C have a pH level of 5.5 to 7.5. Accessed 08/19/2011, Pformulate. Check if any food or ingredient has gluten Simply scan a food product with Fig. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness. Jai Radhe Sales Paldi, Ahmedabad TrustSEAL Verified View Mobile Number Contact Supplier Request a quote Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Starch glycolates are of rice, potato, wheat or corn inception. 1 rating. 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